Restoring insulin production in type 2 diabetes through weight loss
While there is ongoing research in this area, the concept of restoration of insulin production through weight loss has been demostrated in numerous large scale clinical trials, particularly in the UK. Here's an overview of what the research suggests so far:
Beta cell de-differentiation: Studies suggest that under conditions of chronic hyperglycemia and metabolic stress, beta cells may undergo de-differentiation, meaning they lose their specialized function as insulin-producing cells. Instead, they may adopt a more progenitor-like state or even transform into other cell types. It is observed that fat build up in the pancrease accompanies beta cell loss of function, meaning reduced insulin production.
Weight loss and beta cell function: Weight loss, particularly through lifestyle interventions such as diet and exercise, has been shown to improve insulin sensitivity and glycemic control in individuals with type 2 diabetes. Research suggests that weight loss leads to improvements in beta cell function ie insulin production.
Beta cell regeneration: While beta cell de-differentiation has been observed, there is also evidence to suggest that beta cells have the capacity to regenerate and proliferate under certain conditions. Studies have demonstrated that beta cell mass can increase in response to factors such as weight loss and exercise.
Not all individuals with type 2 diabetes will experience significant improvements in beta cell function with weight loss. Research suggests that there is a limited time in which beta cells can be regenerated (within 10 years of diagnosis). In addition to disease duration other factors such as, severity, and genetic predisposition may influence the likelihood of beta cell restoration.
People who achieve type 2 diabetes remission cut rates of heart and kidney disease by more than 30% according to the The Look AHEAD trial which involved 5,000 people with type 2 diabetes and looked at the effect of lifestyle changes on weight loss and heart health.
In summary, there is a growing consensus that weight loss can improve beta cell function and even promote beta cell regeneration in individuals with type 2 diabetes. Diabetes progression can be halted rather than managed. People can aspire to reducing anti-diabetic medications or eliminating them in many cases, but steps need to be taken urgently from diagnosis with the assistance of a healthcare professional.
